Women who smoke and have a specific genetic makeup are at significant risk for the development of breast cancer, according to a recent study published by the journal Cancer Epidemiology, Biomarkers and Prevention.

A research group led by Christine Ambrosone, PhD, Cancer Prevention and Population Sciences Program, Roswell Park Cancer Institute (RPCI) and Jenny Chang-Claude, PhD, Professor in Epidemiology at University of Heidelberg analyzed data from 10 of the 13 studies published in the last 10 years in which they evaluated genetic information, smoking habits and breast cancer risk in 4,889 premenopausal and 7,033 postmenopausal women.

Analysis demonstrated a significant interaction between breast cancer risk, smoking, and a specific gene called the NAT2 that produces the enzyme, N-acetyltransferase 2 (NAT2).